Huntingtin Interactions with Membrane Phospholipids: Strategic Targets for Therapeutic Intervention?
نویسندگان
چکیده
منابع مشابه
Huntingtin interactions with membrane phospholipids: strategic targets for therapeutic intervention?
The Huntington's disease gene encodes the protein huntingtin (Htt), a soluble protein that largely distributes to the cytoplasm where about half the protein is found in association with membranes. Early studies on Huntington's disease patients suggested changes in membrane phospholipids. Furthermore, changes in phospholipid biosynthetic enzymes have been found in HD cell models using genetic me...
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We have identified a domain in the N terminus of huntingtin that binds to membranes. A three-dimensional homology model of the structure of the binding domain predicts helical HEAT repeats, which emanate a positive electrostatic potential, consistent with a charge-based mechanism for membrane association. An amphipathic helix capable of inserting into pure lipid bilayers may serve to anchor hun...
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ژورنال
عنوان ژورنال: Journal of Huntington's Disease
سال: 2013
ISSN: 1879-6397
DOI: 10.3233/jhd-130068